Get Advances in Human Genetics 10 PDF

By Winifred M. Watkins (auth.), Harry Harris, Kurt Hirschhorn (eds.)

ISBN-10: 1461582881

ISBN-13: 9781461582885

ISBN-10: 1461582903

ISBN-13: 9781461582908

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I and 2. Chapter 1: ABO, Lewis, and P Blood Group Systems 31 activity of the glycolipid with all the anti-l reagents. 3-galactosyl end-group and a second category reacting with an internal part of the glycolipid chain of which N-acetylglucosamine is an essential constituent (Fig. 5). , 1975). On the basis of their reaction in quantitative precipitation assays with various purified blood group substances from human ovarian cysts, anti-I sera were classified into six groups and anti-i sera into four groups (Feizi and Kabat, 1972).

A sharp distinction between antibodies detecting the Type 1 and Type 2 H determinants would be in accord with the observations of Lemieux (1978) that from a stereochemical point of view the two determinants are vastly different molecular structures. , 1978b). Hence, although the erythrocytes can acquire blood-group-active glycosphingolipids from lipoproteins in the plasma, no exchange would be expected to occur between the plasma and the blood-group-active glycosphingolipids that are synthesized by the red cell precursors.

I and 2. Fuc {l-GaIU-4){l-GlcNAcU - 6){l-Gal. Type X IV active structure (Oetermi nant recognized by some anti-I sera) threonine residues were substituted with carbohydrate chains. Isolation of a few pure peptides from the chemical degradation products of a pronase-digested glycoprotein revealed dense packing of the serine and threonine residues in the region of the peptide core carrying the carbohydrate chains (Goodwin and Watkins, 1974). No recognition signal for the initiation of glycosylation of the peptide chains is readily apparent from the amino acid sequences established, and it seems probable that for the aN-acetylgalactosaminytransferase adding the first sugar to a serine or threonine residue, the conformation of the peptide is more important than the precise amino acid sequence.

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Advances in Human Genetics 10 by Winifred M. Watkins (auth.), Harry Harris, Kurt Hirschhorn (eds.)


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