By Teresa Rocha-Santos, Armando C. Duarte
Seas and oceans supply quite a lot of temperature, strain, gentle and chemical conditions thus permitting a large range of marine organisms from shallow coastal waters to the deep ocean. those assets can be utilized to procure new items and boost companies, and in flip support to provide solutions to the demanding situations that impact our planet, together with delivering a sustainable offer of foodstuff and effort, new business fabrics and strategies, new bioactive compounds, and new overall healthiness remedies. Marine compounds were pointed out as having antibacterial, anticoagulant, antifungal, antimalarial, antiprotozoal, antituberculosis, and antiviral actions. the key assets of those bioactive compounds are marine sponges, coelenterates, and microorganisms, through algae, echinoderms, tunicates, molluscs, and bryozoans.
The discovery of bioactive compounds from marine samples is a scorching subject contemplating the present need for sustainable use of marine assets. This booklet is a entire assessment of the analytical techniques employed within the discovery and characterization of bioactive compounds remoted from (all attainable) marine samples and offers destiny views of analytical methodologies. This evaluate comprises an overview of the sampling and guidance of extracts, the separation and isolation of bioactive compounds, their structural characterization and the appliance of bioassays within the discovery of bioactive compounds.
- Comprehensive insurance of analytical strategies and applications
- Clear diagrams to competently help vital topics
- Real examples of purposes of analytical ideas within the look for new bioactive compounds
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Additional resources for Analysis of Marine Samples in Search of Bioactive Compounds
31] Petromica citrina Rio de Janeiro, Brazil Sterol: halistanol trisulphate Methanol Solvent partition into hexane, chloroform, and ethyl acetate, as well as into aqueous residue. The aqueous residue fraction (better bioactivity) was purified with Sephadex LH-20 column chromatography (eluted with a system of solvents of different polarity from water to methanol). 2 Methods of Extraction and Fractionation for the Isolation of Bioactive Compounds from Marine Organisms such as Sponges, Plants, and Mollusks 43 Origin Bioactive Compounds Solvent Extraction Fractionation and Purification Reference Lanthella cf.
64] reported that bioactive hydrophilic compounds can also be obtained from marine fungi. For example, novel hydrophilic compounds hypochromins A and B were isolated from the specie Hypocrea vinosa, showing the higher inhibitory activity when obtained from the ethanol extract of such fungi specie . Le Ker et al.
According to Bhakuni and Rawat , for example, the lipophilic compounds are mostly present in the hexane and chloroform fractions, and the nonpolar compounds that are extracted in hexane, benzene, and chloroform are generally esters, ethers, terpenoids, sterols, and fatty acids. The extraction by solvents could follow the principle of either “liquidliquid” or “solid-liquid” extractions. The liquid-liquid extraction is the classical technique in chemistry to isolate a target component from a mixture.
Analysis of Marine Samples in Search of Bioactive Compounds by Teresa Rocha-Santos, Armando C. Duarte